This giant cell variant of malignant fibrous histiocytoma was seen only in cats these tumors are comparable to those described in man as malignant fibrous histiocytoma on the basis of the malignant histiocyte and its varied morphology and function since the description of malignant fibrous xanthomas in man in 1964 there has. Five soft tissue tumors of varied morphology in dogs and cats were classified as malignant fibrous histiocytomas on the basis of their histologic composition all were composed of varying mixtures malignant fibrous histiocytoma in dogs and cats c a gleiser g l raulston j h jardine k n gray 1979 skip to main content. Five soft tissue tumors of varied morphology in dogs and cats were classified as malignant fibrous histiocytomas on the basis of their histologic composition all were composed of varying mixtures of histiocytes and fibroblasts and three contained large multinucleated cells. Research in veterinary science 1992 53 198 204 malignant fibrous histiocytomas in dogs and cats an immunohistochemical study r j m m thoolen j h vos j s van der linde sipman r a de weger j a m van unnik w misdorp j e van dijk department of veterinary pathology branch laboratory animal pathology and special animal diseases faculty of veterinary medicine